US-Based & OperatedExosomes · Topical cosmetic
Exosome skincare, explained clearly.
A science-first look at exosome-based topical skincare — from what exosomes are and how they're characterized to why they're being studied in skin science.
Form
Topical cosmetic
Focus
Skin appearance
Science
Exosomes & extracellular vesicles
The basics
What exactly is an exosome?
Exosomes are nanoscale extracellular vesicles released by cells. They are part of a broader family of membrane-bound vesicles involved in cell-to-cell communication, and can carry molecular cargo including proteins, lipids and nucleic acids.
Extracellular vesicles
Small membrane-bound structures
Exosomes belong to a broader family of extracellular vesicles released by cells.
Molecular cargo
What's inside?
Extracellular vesicles can contain proteins, lipids and nucleic acids associated with the cells that produced them.
Cell communication
Why researchers study them
Researchers study extracellular vesicles for their role in biological signaling and communication between cells.
Exosome terminology
“Exosome” is commonly used in research and commercial settings, but identifying a preparation specifically as exosomes requires appropriate characterization. Depending on how a preparation is isolated and analyzed, the broader term extracellular vesicles (EVs) may be more scientifically precise.
What it's for
Cosmetic support for how skin looks
The topical exosome-based products offered through Stem Nova Direct are cosmetic products. The claims below relate to the appearance of skin — not the diagnosis, treatment, cure, or prevention of disease.
A healthy-looking glow
Used topically to support the appearance of radiant, refreshed-looking skin.
Smoother-looking texture
Formulated to complement a skincare routine focused on the look and feel of skin texture.
More even-looking tone
Intended to support the appearance of a more even, well-rested-looking complexion.
Where it comes from
From cells to extracellular vesicles.
Exosomes and other extracellular vesicles are released naturally by cells. For exosome-based skincare, the process begins with a defined cell source and continues through controlled culture, collection, processing and characterization before incorporation into a topical formulation.
- 01
Cell source
Mesenchymal stromal/stem cells
A defined cell population serves as the biological source.
- 02
Cell culture
Cells are expanded under controlled conditions
As cells grow in culture, they release signaling molecules and extracellular vesicles into their surrounding environment.
- 03
Collection
Conditioned media / secretome
The surrounding culture media contains materials released by the cells, including extracellular vesicles and other secreted components.
- 04
Processing
EV-rich material is processed
The collected material undergoes defined processing steps before characterization.
- 05
Characterization
What was actually produced?
Analytical methods evaluate attributes such as particle concentration, size distribution and other characteristics appropriate to the preparation.
Exosomes are not stem cells
Exosomes are extracellular vesicles released by cells. They do not contain living stem cells and should not be confused with the cells that produced them.
Clear boundaries
What it is, and what it isn't
It is
- A topical cosmetic skincare product
- Designed for the appearance of skin
- Applied to the skin's surface
It isn't
- Not an injectable
- Not a drug or medical treatment
- Not intended to diagnose, treat, cure, or prevent disease
The Product
Meet NovaCore
NovaCore is Stem Nova's topical cosmetic secretome concentrate and Step 1 of the two-step NovaRenew professional skincare system. It is designed for topical cosmetic use on the skin's surface.
NovaRenew™ is a two-step professional system — NovaCore (Step 1) and Renew (Step 2).
Product at a glance
NovaCore · Stem Nova's topical cosmetic secretome
- Volume
- 2 mL per vial
- Particle characterization
- ≈ 66 billion particles per vial (NTA)
- Composition
- Cell-free secretome — no living cells
- Form
- Topical cosmetic — applied to the skin's surface
- Manufacturing
- Manufactured in the USA
- Use
- Professional cosmetic use, at the practitioner's discretion
“≈ 66 billion particles per vial” is a nanoparticle-tracking-analysis (NTA) particle count reported by Stem Nova — a physical measurement of particle concentration, not a statement of cosmetic performance or biological effect.
If you're exploring skincare
What NovaRenew includes
Nova Core — Step 1
Secretome Concentrate
Topical cosmetic secretome concentrate containing the characterized extracellular-vesicle preparation described above.
Renew — Step 2
GHK-Cu (copper peptide) + PDRN Conditioning Formulation
A complementary topical formulation containing GHK-Cu and PDRN, applied as the second step of the NovaRenew system.
For licensed professionals
The NovaRenew two-step system
NovaRenew is a two-step professional cosmetic skincare system designed for use by licensed skincare professionals, consistent with product labeling and applicable scope-of-practice requirements.
NovaCore — Secretome Concentrate
The topical cosmetic secretome concentrate.
Renew — Conditioning Formulation
The second topical step in the NovaRenew skincare system, formulated with GHK-Cu (copper peptide) and PDRN.
Wholesale access is available to licensed professionals only, following credential verification. Orders include lot-specific Certificate of Analysis documentation.
Licensed professional? Ask about wholesale accessDocumentation
What a released lot documents
NovaCore is released with lot-specific documentation. Safety-related assays are tested against fixed release specifications; particle concentration is characterized by nanoparticle tracking analysis (NTA). The values below are transcribed from one released lot as an example — each lot's own documents are the authoritative record. This documentation reflects product testing and characterization, not an FDA approval or any cosmetic performance claim.
Certificate of Analysis
CORE-V1-N23 · Lot 3D-210-B
- 1
Product & lot
— CORE-V1-N23 · Lot 3D-210-B
Identifies the exact production lot. Every result applies only to this lot, not to the product in general.
- 2
Volume
— 2 mL per vial
The fill volume documented for the vial.
- 3
Manufacture & release dates
— Manufactured March 2026 · Released April 29, 2026
When the lot was produced, and when it cleared release testing.
- 4
Safety-related testing
— Sterility: No growth · Mycoplasma: Negative · Endotoxin: < 0.04 EU/mL
Microbiological release testing measured against fixed pass/fail specifications, consistent from lot to lot.
- 5
Particle characterization (NTA)
— ≈ 66 billion particles per vial
Nanoparticle tracking analysis measures particle size and concentration. This is a physical particle count — a measurement, not a statement of cosmetic performance.
Documentation reflects product testing and characterization only. It is not an FDA approval and not a cosmetic performance claim. NovaCore is a topical cosmetic product; it is not injected and is not a medical treatment.
Looking into regenerative options instead?
Exosome-based topical skincare is separate from our education-and-referral path for regenerative options involving stem cells. If that's what you're exploring, start with the science.